B-vitamins, genotype and disease causality

Associations between B Vitamins and Parkinson’s Disease

B vitamins may correlate with Parkinson's disease (PD) through regulating homocysteine level. However, there is no comprehensive assessment on the associations between PD and B vitamins. The present study was designed to perform a meta-analytic assessment of the associations between folate, vitamin B6, and vitamin B12 and PD, including the status of B vitamins in PD patients compared with contr...

Homocysteine, B-vitamins, and the risk of cardiovascular disease.

Featured Article: Clarke R, Daly L, Robinson K, Naughton E, Cahalane S, Fowler B, Graham I. Hyperhomocysteinemia: an independent risk factor for vascular disease. N Engl J Med 1991;324:1149 –55. Our report, published in the New England Journal of Medicine in 1991, demonstrated that hyperhomocysteinemia was present in about one-third of cases with early-onset coronary heart disease, cerebral vas...

Preventing coronary heart disease: B vitamins and homocysteine.

The list of preventable and reversible risk factors for atherosclerotic cardiovascular disease continues to grow. Cigarette smoking, high blood pressure, physical inactivity, elevated cholesterol, underlying lipoprotein abnormalities, lipoprotein(a), diabetes, overweight, male gender, and age are well-established risk factors. During the 1990s, there have been many reports associating elevated ...

Homocysteine, B vitamins, and risk of cardiovascular disease.

Vitamins and cardiovascular disease.

CVD is a major cause of mortality and morbidity in the Western world. In recent years its importance has expanded internationally and it is believed that by 2020 it will be the biggest cause of mortality in the world, emphasising the importance to prevent or minimise this increase. A beneficial role for vitamins in CVD has long been explored but the data are still inconsistent. While being supp...